Our research integrates human genetics with animal models to delve into the molecular and neurocircuitry mechanisms underlying various human conditions. Our team is primarily focused on two key areas: neurodegenerative and episodic disorders, as well as circadian rhythm and sleep behaviors. Through a comprehensive exploration of these conditions, our objective is twofold: first, to develop innovative strategies for early detection, intervention, and improved disease management; and second, to explore the potential for promoting healthy longevity. By unraveling the intricacies of these conditions, we strive to make significant contributions to the field of biomedical research.