Biological rhythms govern the ebb and flow of life on planet Earth. Animals have an internal timekeeping mechanism that precisely regulates 24-hour rhythms of body function and behavior and synchronizes them to the day/night cycle.
Neurodegenerative disorders are among the most common to affect us as we age. They include, but are not limited to, Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS, Lou Gehrig's disease), and Multiple Sclerosis
Episodic phenomena are common in humans. These include (but are not limited to) seizures, headaches, cardiac arrhythmias, episodic movement disorders, and periodic paralyses. These disorders have strong genetic
Identification of genetic contributions to normal variation and diseases of the nervous system through study of families with these disorders is shedding new light on the normal function of the human brain and the pathology of many human neurological diseases. Bridging the gap from bedside to bench will allow new opportunities for translating basic knowledge